Protein Purification
Echelon Biosciences Research Labs AS604850 (PI3-K gamma Inhibitor 2) 1 mg
5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione (AS604850) is an inhibitor of PI 3-K with an IC50 = 250 nM. AS604850 is selective for the -isoform (IC50: PI 3-K = 4.5 M, PI 3-K, PI 3-K > 20 M) and shows no notable activity against a wide array of protein kinases at 1 M.nn
nn
Solubility
nWater: insoluble, DMSO: 5 mg/mLnStorage
nStore dry between 2-8oC. Stock solutions should be stored frozen (-20oC).nReferences
n1) M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis" Nature Medicine, 2005, 11, 936-943.nnnn
Documents
nTechnical Data Sheet This item is non returnable
Cayman Chemical HIV-1 Integrase InhIbItr 25mg
An inhibitor of HIV-1 integrase strand transfer (IC50s = 0.07 and 0.33 µM in the presence of manganese and magnesium, respectively); selective for strand transfer over 3ʹ DNA processing (IC50 = >70 µM in the presence of either manganese or magnesium); selective for wild-type HIV-1 integrase over HIV-1 integraseF185K/C280S (IC50 = 1.53 µM in the presence of manganese); reduces the secreted levels of p24 in CEM-SS and H9 cells (IC50s = 11 and 7 µM, respectively) without inducing cytotoxicity (CC50s = 600 and 400 µM, respectively)
Cayman Chemical Mps1tK InhIbItr 25mg
An inhibitor of Mps1/TTK (IC50 = 5.8 nM); inhibits Mps1 phosphorylation of KNL1 and increases the rate of mitosis at 100 nM; increases the number of missegregated chromosomes at 50 and 100 nM; inhibits colony formation of DLD1, HCT116, and U2OS cells (IC50s = 24.6, 20.1, and 20.6 nM, respectively)
Bon Opus Biosciences Recombinant Human Apolipoprotein E/ ApoE (C-His, Expi293) -500ug
Recombinant Human Apolipoprotein E is produced by Human 293 Cells and the target gene encoding Lys19?His317 is expressed with a 6His tag at the C?terminus. Expression system: Human 293 Cells. Accession# P02649. Formulation: Lyophilized frum a 0.2 um filtered solution of 2umM PBS, 5mM CHAPS, 2mM DDT, pH7.4. Bon Opus Cat# BP120
Gentarget LVP1131-GP-PBS, pre-made lentivirus for hTERT expression, 1 x 10^8 IFU/ml, 200 μl/vial, PBS solution, GFP-Puromycin selection, Enhanced EF1a promoter
LVP1131-GP-PBS, pre-made lentivirus for hTERT expression, 1 x 10^8 IFU/ml, 200 μl/vial, PBS solution, GFP-Puromycin selection, Enhanced EF1a promoter
Abcam Donepezil hydrochloride, Acetylcholinesterase inhibitor, 50MG
MW 415.96 g/mol, Purity >99%. Potent, selective acetylcholinesterase inhibitor (IC₅₀ = 5.7 nM). Displays >1250 times selectivity for AChE over butyrylcholinesterase. Centrally active. Neuroprotective activity in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement